OUR JOINT ACHIEVEMENTS

List of publications written jointly by the participants of the symposium

Antoniuk, S., Bijata, M., Ponimaskin, E., Wlodarczyk, J., 2019. Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability. Neurosci Biobehav Rev 99, 101–116.

Canale, V., Grychowska, K., Kurczab, R., Ryng, M., Keeri, A.R., Satała, G., Olejarz-Maciej, A., Koczurkiewicz, P., Drop, M., Blicharz, K., Piska, K., Pękala, E., Janiszewska, P., Krawczyk, M., Walczak, M., Chaumont-Dubel, S., Bojarski, A.J., Marin, P., Popik, P., Zajdel, P., 2020. A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties. Eur J Med Chem 208, 112765.

Drop, M., Canale, V., Chaumont-Dubel, S., Kurczab, R., Satała, G., Bantreil, X., Walczak, M., Koczurkiewicz-Adamczyk, P., Latacz, G., Gwizdak, A., Krawczyk, M., Gołębiowska, J., Grychowska, K., Bojarski, A.J., Nikiforuk, A., Subra, G., Martinez, J., Pawłowski, M., Popik, P., Marin, P., Lamaty, F., Zajdel, P., 2021. 2-Phenyl-1H-pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT6 Receptor Inverse Agonists with Cognition-Enhancing Activity. ACS Chem Neurosci 12, 1228–1240.

Gorinski, N., Bijata, M., Prasad, S., Wirth, A., Abdel Galil, D., Zeug, A., Bazovkina, D., Kondaurova, E., Kulikova, E., Ilchibaeva, T., Zareba-Koziol, M., Papaleo, F., Scheggia, D., Kochlamazashvili, G., Dityatev, A., Smyth, I., Krzystyniak, A., Wlodarczyk, J., Richter, D.W., Strekalova, T., Sigrist, S., Bang, C., Hobuß, L., Fiedler, J., Thum, T., Naumenko, V.S., Pandey, G., Ponimaskin, E., 2019. Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors. Nature Communications 10, 1–14.

Gorinski, N., Wojciechowski, D., Guseva, D., Galil, D.A., Mueller, F.E., Wirth, A., Thiemann, S., Zeug, A., Schmidt, S., Zareba-Kozioł, M., Wlodarczyk, J., Skryabin, B.V., Glage, S., Fischer, M., Al-Samir, S., Kerkenberg, N., Hohoff, C., Zhang, W., Endeward, V., Ponimaskin, E., 2020. DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels. J. Biol. Chem. 295, 5970–5983.

Grychowska, K., Chaumont-Dubel, S., Kurczab, R., Koczurkiewicz, P., Deville, C., Krawczyk, M., Pietruś, W., Satała, G., Buda, S., Piska, K., Drop, M., Bantreil, X., Lamaty, F., Pękala, E., Bojarski, A.J., Popik, P., Marin, P., Zajdel, P., 2019. Dual 5-HT6 and D3 Receptor Antagonists in a Group of 1H-Pyrrolo[3,2-c]quinolines with Neuroprotective and Procognitive Activity. ACS Chem Neurosci 10, 3183–3196.

Guseva, D., Rüdrich, U., Kotnik, N., Gehring, M., Patsinakidis, N., Agelopoulos, K., Ständer, S., Homey, B., Kapp, A., Gibbs, B.F., Ponimaskin, E., Raap, U., 2020. Neuronal branching of sensory neurons is associated with BDNF-positive eosinophils in atopic dermatitis. Clin Exp Allergy 50, 577–584.

Hogendorf, A.S., Hogendorf, A., Kurczab, R., Kalinowska-Tłuścik, J., Popik, P., Nikiforuk, A., Krawczyk, M., Satała, G., Lenda, T., Knutelska, J., Bugno, R., Staroń, J., Pietruś, W., Matłoka, M., Dubiel, K., Moszczyński-Pętkowski, R., Pieczykolan, J., Wieczorek, M., Pilarski, B., Zajdel, P., Bojarski, A.J., 2019a. 2-Aminoimidazole-based antagonists of the 5-HT6 receptor – A new concept in aminergic GPCR ligand design. Eur J Med Chem 179, 1–15.

Hogendorf, A.S., Hogendorf, A., Popiołek-Barczyk, K., Ciechanowska, A., Mika, J., Satała, G., Walczak, M., Latacz, G., Handzlik, J., Kieć-Kononowicz, K., Ponimaskin, E., Schade, S., Zeug, A., Bijata, M., Kubicki, M., Kurczab, R., Lenda, T., Staroń, J., Bugno, R., Duszyńska, B., Pilarski, B., Bojarski, A.J., 2019b. Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers. Eur J Med Chem 170, 261–275.

Koroleva, A., Deiwick, A., El-Tamer, A., Koch, L., Shi, Y., Estévez-Priego, E., Ludl, A.-A., Soriano, J., Guseva, D., Ponimaskin, E., Chichkov, B., 2021. In Vitro Development of Human iPSC-Derived Functional Neuronal Networks on Laser-Fabricated 3D Scaffolds. ACS Appl Mater Interfaces 13, 7839–7853.

Labus, J., Röhrs, K.-F., Ackmann, J., Varbanov, H., Müller, F.E., Jia, S., Jahreis, K., Vollbrecht, A.-L., Butzlaff, M., Schill, Y., Guseva, D., Böhm, K., Kaushik, R., Bijata, M., Marin, P., Chaumont-Dubel, S., Zeug, A., Dityatev, A., Ponimaskin, E., 2020. Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor. Prog Neurobiol 101900.

Lacivita, E., Niso, M., Mastromarino, M., Garcia Silva, A., Resch, C., Zeug, A., Loza, M.I., Castro, M., Ponimaskin, E., Leopoldo, M., 2021. Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder. ACS Chem Neurosci 12, 1313–1327.

Martin, P.-Y., Doly, S., Hamieh, A.M., Chapuy, E., Canale, V., Drop, M., Chaumont-Dubel, S., Bantreil, X., Lamaty, F., Bojarski, A.J., Zajdel, P., Eschalier, A., Marin, P., Courteix, C., 2020. mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment. Prog Neurobiol 193, 101846.

Podlewska, S., Bugno, R., Lacivita, E., Leopoldo, M., Bojarski, A.J., Handzlik, J., 2021. Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2. Int J Mol Sci 22, 1035.

Popik, P., Krawczyk, M., Kuziak, A., Bugno, R., Hogendorf, A., Staroń, J., Nikiforuk, A., 2019. Serotonin type 5A receptor antagonists inhibit D-lysergic acid diethylamide discriminatory cue in rats. J Psychopharmacol 33, 1447–1455.

Schill, Y., Bijata, M., Kopach, O., Cherkas, V., Abdel-Galil, D., Böhm, K., Schwab, M.H., Matsuda, M., Compan, V., Basu, S., Bijata, K., Wlodarczyk, J., Bard, L., Cole, N., Dityatev, A., Zeug, A., Rusakov, D.A., Ponimaskin, E., 2020. Serotonin 5-HT 4 receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin. Communications Biology 3, 1–16.

Sonnenberg, S.B., Rauer, J., Göhr, C., Gorinski, N., Schade, S.K., Abdel Galil, D., Naumenko, V., Zeug, A., Bischoff, S.C., Ponimaskin, E., Guseva, D., 2021. The 5-HT4 receptor interacts with adhesion molecule L1 to modulate morphogenic signaling in neurons. J Cell Sci 134, jcs249193.

Staroń, J., Kurczab, R., Warszycki, D., Satała, G., Krawczyk, M., Bugno, R., Lenda, T., Popik, P., Hogendorf, A.S., Hogendorf, A., Dubiel, K., Matłoka, M., Moszczyński-Pętkowski, R., Pieczykolan, J., Wieczorek, M., Zajdel, P., Bojarski, A.J., 2020. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties. Eur J Med Chem 185, 111857.

Vanda, D., Canale, V., Chaumont-Dubel, S., Kurczab, R., Satała, G., Koczurkiewicz-Adamczyk, P., Krawczyk, M., Pietruś, W., Blicharz, K., Pękala, E., Bojarski, A.J., Popik, P., Marin, P., Soural, M., Zajdel, P., 2021. Imidazopyridine-Based 5-HT6 Receptor Neutral Antagonists: Impact of N1-Benzyl and N1-Phenylsulfonyl Fragments on Different Receptor Conformational States. J Med Chem 64, 1180–1196.

Zaręba-Kozioł, M., Bartkowiak-Kaczmarek, A., Roszkowska, M., Bijata, K., Figiel, I., Halder, A.K., Kamińska, P., Müller, F.E., Basu, S., Zhang, W., Ponimaskin, E., Włodarczyk, J., 2021. S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity. Int J Mol Sci 22, 6253.

Funds obtained for joint projects:

·        “The place does matter – 5-HT7R-mediated structural plasticity in the specific hippocampal subregions” SONATA NCN 2019/35/D/NZ4/02042

·        “Therapeutic potential of biased 5-HT7 receptor ligands in the treatment of Depression” OPUS NCN 2019/33/B/NZ7/02822

·        “Zinc deficient diet as a trigger for treatment-resistant depression in chronically stressed mice. Understanding the mechanisms of treatmentresistant depression and overcoming it.” OPUS NCN 2020/37/B/NZ5/03891